effect of pulsed wave low-level laser therapy on tibial complete osteotomy model of fracture healing with an intramedullary fixation

conclusions this study confirmed the efficacy of pw lllt on biomechanical strength, trabecular bone volume, callus volume, and osteoblast number of repairing callus in a complete tibial osteotomy animal model at a relatively late stage of the bone healing process. materials and methods this experimental study was conducted at shahid beheshti university of medical sciences in tehran, iran. we performed complete tibial osteotomies in the right tibias for the population of 15 female rats. the rats were divided randomly into three different groups: i) control rats with untreated bone defects; ii) rats irradiated by a 0.972 j/cm2 pw lllt; and iii) rats irradiated by a 1.5 j/cm2 pw lllt. the right tibias were collected six weeks following the surgery and a three-point bending test was performed to gather results. immediately after biomechanical examination, the fractured bones were prepared for histological examinations. slides were examined using stereological method. results pw lllt significantly caused an increase in maximum force (n) of biomechanical repair properties for osteotomized tibias in the first and second laser groups (30.0 ± 15.9 and 32.4 ± 13.8 respectively) compared to the control group (8.6 ± 4.5) lsd test, p = 0.019, p = 0.011 respectively). there was a significant increase in the osteoblast count of the first and second laser groups (0.53 ± 0.06, 0.41 ± 0.06 respectively) compared to control group (0.31 ± 0.04) (lsd test, p = 0001, p = 0.007 respectively). background fractures pose a major worldwide challenge to public health, causing tremendous disability for the society and families. according to recent studies, many in vivo and in vitro experiments have shown the positive effects of pw lllt on osseous tissue. objectives the aim of this study was to evaluate the outcome of infrared pulsed wave low-level laser therapy (pw lllt) on the fracture healing process in a complete tibial osteotomy in a rat model, which was stabilized by an intramedullary pin.